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 Nulliparity and Multiparity Question?  

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Hello Everybody,

Risk factors are big on the USMLE Step 2 CK, so I was wondering why nulliparity is a + risk factor for Osteoporosis, Breast Cancer, and Endometrial Cancer? It doesn't make sense for it to cause osteoporosis(decreased estrogen) AND endometrial/breast CA (increased estrogen).

Can anybody help?


because expose longer to estrogen


but nulliparity isn't risk factor for osteoporosis
for breast cancer and endometrial cancer yes, but not for osteoporosis, because these tumors are estrogen-dependent
for osteoporosis there are other risk factors:
fair-skinned, slender, white woman with a positive family history, and cigarette smoking is a lifestyle factor associated with the development of osteoporosis


good Q


Center for Health Research, Kaiser Permanente Northwest/Hawaii, Portland, Oregon 97227-1098, USA.

Whether nulliparity increases fracture risk is unclear from prior studies, which are limited by small samples or lack of measured bone mineral density. No study has evaluated whether the effect of parity differs by skeletal site.Compared with parous women, nulliparous women had an increased risk of hip and spine, but not wrist, fractures. In multivariate models, parity remained a significant predictor only for hip fracture. Nulliparous women had a 44% increased risk of hip fractures independent of hip bone mineral density

osteopenia and osteoporosis were most often present in nulliparous women in comparison to multiparous women. Pregnancies appear to be a protective factor against development of osteoporosis. The increase in total mineral and calcium contents was related to the number of pregnancies, suggesting the existence of a bone mass peak during pregnancy.

Nulliparity is the risk factor for development of osteoporosis in posmenopausal women.
I hope you found here the answer on this question :-)

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