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 screening for chronic hepatitis C  



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Author5 Posts
  #1

What is it used for screening in HVC?
I know that the sequence is anti HCV antibodies by EIA; then for confirmation-HCV RNA, which is marker of replication, treatment-decision making and treatment monitoring.





  #2

for treatment, any patient with modest elevation of transaminases should be started on peg interferon or ribavirin.


  #3

does hcv viral load play any role in deciding management or is it only the transaminases which decide treatment?
what would be the line of management if the hcv viral load were high and transaminases were normal??


  #4

My intial question was about screening in HCV.
WHEN to treat is as follows:
-patients with chronic hepatitis C and HCV RNA in serum>50 IU/mL
-HCV genotype-it's very imprtant because genotype 1a and 1b that are 75% prevalence in the USA have the lowest sustained viral response (SVR) at 48 weeks (~40%) while genotypes 2 and 3 have a much better SVR at 48 weeks (70-80%)
-raised serum ALT,
-chronic hepatitis of at least moderate severity on a liver biopsy specimen (presence of bridging fibrosis or moderate degrees of inflammation and necrosis),
-no contraindications to treatment.
Between ALT and HCV genotype, genotype is much more important.



  #5

good explanation odin. thanks a lot. i think u have answered all the questions by urself.





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