Prep for USMLEPrep for USMLE
         Forum      |     Resources New Posts   |   Register   |   Login


Post Reply  
  • 0/5
  • 1
  • 2
  • 3
  • 4
  • 5

Author7 Posts

fragile X syndrome is X linked recessive according to FA,
it is X linked dominant acc to Kaplan.

Which is correct?


Fragile X syndrome is an X-linked dominant condition with reduced penetrance.


X linked dominantnod


It is classified under non-mendelian inheritance & it is X-Linked Inheritance, it does not follow the patterns for normal X-linked recessive or dominant mutation. Females are affected differently than males. The penetrance in male is 100% and females 60%.


That's a really interesting question...and I say this because I was convinced it was X linked dominant since the females are also affected.Problem is that Goljan RR also puts it in the X recessive category...Kaplan sais it's X-linked dominant,and due to the big percentage of women affected (even if milder), I would go with Kaplan - X linked dominant.
Again,a very interesting issue.


I think it's been discussed and debated before as wellgrin


I think for USMLE exam purposes we should select what is Kaplan's answer.

Bookmark and Share

This thread is closed, so you cannot post a reply.

Login or Register to post messages

show Similar forum topics

Fragile X syndrome
Fragile X syndrome continues
Fragile X-syndrome
show Related resources

Advertise | Support | Premium | Contact