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 Dominant negative mutation  



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Author5 Posts
  #1

Hi all,

On the p.88 of FA 2009 ed, there is:

" Dominant negative effect : Exerts a dominant effect. A heterozygote produces a nonfunctional altered protein that also prevents the normal gene product from functioning''

Can someone tell me the example of this, I'm so tired of thinking and looking for it. I remember reading about it, but can not recall. Can you help me out ?

Thanks




  #2

hi GG,
marfan syndrome do exhibit this dominant negative effect..also known as antimorphism..
In marfan syndrome the defective glycoprotein product of the fibrillin gene (FBN1) antagonizes the product of the normal allele.


  #3

Really ? Thanks, I did not know that. Interesting.

Any other disease ?


  #4

well i dont knw if any other disease in humans exhibits antimorphism.raised eyebrow...but there are many instances of this mutation in the drosophila fly!!


  #5

wink





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