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 Dominant negative mutation  

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Hi all,

On the p.88 of FA 2009 ed, there is:

" Dominant negative effect : Exerts a dominant effect. A heterozygote produces a nonfunctional altered protein that also prevents the normal gene product from functioning''

Can someone tell me the example of this, I'm so tired of thinking and looking for it. I remember reading about it, but can not recall. Can you help me out ?



hi GG,
marfan syndrome do exhibit this dominant negative effect..also known as antimorphism..
In marfan syndrome the defective glycoprotein product of the fibrillin gene (FBN1) antagonizes the product of the normal allele.


Really ? Thanks, I did not know that. Interesting.

Any other disease ?


well i dont knw if any other disease in humans exhibits antimorphism.raised eyebrow...but there are many instances of this mutation in the drosophila fly!!



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