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female patient came to the dotor with abdominal pain in epigasric region , he diagnosed her with 'gastric sarcoma', which gene is involved???
2.tyrosine kinase




ret : Men II and Men III
msh-2 : HNPC
APC: Familial denomatous Polyps




ret gene involved in MEN 1


I apologize my mistake it is involved in MEN 2 and 3 but those dont include gastric saromas, so that would not be a good choice. Please, any thoughs?


am asked what is the answer??
am not with ret
i exclude 3,4and 5


most of the gastric stromal tumors have mutations in c-KIT and PDGF receptor alpha genes, both of which have cytoplasmic tyrosine kinases, ultimately affecting this pathway.
so i'll go for 2.

hope it helps!



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