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 inhibin B  

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sorry it was an answer for question posted by dxtx...Previously

It is suppose to be an estrogen. Small quantities of estrogen are secreted by luteal cells of corpus luteum +progesterone. Only estrogen can give a negative feedback for FSH at this situation. Progesterone inhibits LH secretion. this is what you can read for step 1 but :_online_:
Under the control of Gonadotropins (FSH, LH) and Inhibin B, the DOMINANT antral follicle (now 2cm), having completed its development, ruptures under the influence of hormones and the production of suitable enzymes. The ooycyte is duly released.

The fact that only one or, at most, a very few oocytes are ovulated with each cycle, despite the huge number of preantral follicles, is due to the way folliculogenesis is regulated.

There are three stages for a preantral follicle to become a shed oocyte: recruitment, selection and dominance.

Up to five preantral follicles are recruited to the antral stage at each cycle, under the influence of the growing FSH level. The FSH receptors on the follicle cells start to multiply.

As a response to FSH stimulation, the granulosa cells produce Inhibin B which has a negative feedback effect on the pituitary and reduces the release of FSH. As the FSH level falls, only those follicles which have developed sufficient receptors are able to continue.
Final domination is achieved as the follicle expresses hormones for autocrine stimulation of growth and development, as well increasing the aromatase activity for production of estrogenic steroids.

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