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 Growth Hormone - help please  



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Author9 Posts
  #1

Can anyone tell me what inhibits Growth Hormone? What is the negative feedback mechanism?





  #2

growth hormone inhibiting hormone (somatostatin) inhibits it.

growth hormone releasing hormone releases it.

both are from the hypothalamus



  #3

Thanks. smiling face Does glucose inhibit it too? I thought it also did. Assuming that it does, then why can't you use it as a treatment for elevated growth hormone.



  #4

well i have no idea about it.......growth hormone does affect the glucose conc,increases it, but dont know if glucose affects GH conc.......



  #5

GH is considered as a Stress Hormone so hypoglycemia induces its secretion and Hyperglycemia decreases it.



  #6

Much thanks. smiling face



  #7

Just read in RR that "Hormones are not supressed by glucose administration" which is what I knew, but just can't figure out why.



  #8

growth hormone along with cortisol,epinephrine,glucagon are the stress hormones....they are induced by hypoglycemia or any other state of stress and inhibited by hyperglycemia...


  #9

Kaplan: "GH is released in pulses throughout the day. The most consistent period of secretion occurs approximately one hour after the onset of sleep. GH is released following stress, hypoglycemia, vasopressin or L-dopa injection, during exercise, and during sleep"
Also, somatomedins inhibit GH secretion and promote somatostatin secretion.





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