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 Lipid synthesis and storage  

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Abetalipoproteinemia is a genetic disorder characterized by malabosorption of dietary lipid, steatorrhea(fatty stools), accumulation of intestinal triglycerides, and hypolipoproteinemia. Patients with this disorder exhibit membrane abnormatlities in their erythrocyes with production of acanthocytes (thorny appearing cells). This unusual red cell morphology would most likely result from malabsorption of

A. Palmitic Acid
B. Ascorbic acid
C. Arachidonic acid
D. Folic acid
E. Linoleic Acid




I'm thinking it's either D or E,

because palmitic acid is synthesized in our body, Ascorbic acid is water soluble, so it has no problem being absorbed, arachidonic acid is made from linoleic acid,

Linoleic acid is an essential fatty acid from our diet i'm thinking, so i'm leaning more towards the answer E


yes acanthocytes means deformed RBC's...

Iam also thiking in terms of E

But folic acid def .doesnot produce acanthocytes :roll:


Yes the answer is E because linoleic acid is an essential fatty acid and the others are not.


Good call...all you really had to know here is what we cant make/easily absorb. Folate is a good distractor, but is water soluble (we get told over and over that no amount of steatorrhea will affect folate absorption).

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