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oddissy4u
Forum Guru Topics: 107 Posts: 389 |
MOA?
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mdwannabe
| Forum Guru Topics: 37 Posts: 1131
several, PCT reduce Na reabs, nobody knows how, and relax mesangial cells, to increase filtration.
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crista
| Forum Guru Topics: 121 Posts: 402
what's the second messager for it?
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mdwannabe
| Forum Guru Topics: 37 Posts: 1131
my assumption would be cAMP
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mdwannabe
| Forum Guru Topics: 37 Posts: 1131
and cGMP in mesangial matrix
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crista
| Forum Guru Topics: 121 Posts: 402
so both?
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mdwannabe
| Forum Guru Topics: 37 Posts: 1131
honestly I am making a gues here, I do not even know the receptor type that responds to ANP, so I am going by action and intrapolating the 2nd messenger.
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crista
| Forum Guru Topics: 121 Posts: 402
acts by cGMP-for sure it seems to be associated with subarahnoidian hmg. and amiloidosis.
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Malaysian
| Forum Guru Topics: 28 Posts: 778
ANP....Atrial Natriuretic Peptide.....released once receptors in Right Atrium detect an increase in osmolarity....acts by blocking Na reuptake(therefore the natriuretic affect)in the Distal Tubules.It acts via the cGMP receptor mechanism.I've also read somewhere it also blocks synthesis of of ADH in the hypothalamus or was it ADH release from the posterior pituitary?? I'm not sure of its association with Subarachnoid H'hage and amiloidosis though....can anyone shed any light to this but from what i know it is usually released after an episode of PSVT(Paroxysmal Supraventricular Tachycardia)where the patient after an episode of palpitation gives history of mictutition because of the ANP released.
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