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Tiff Forum Guru Topics: 58 Posts: 597	Jan 03, 2008 - 9:25 AM       #1 A 16 year old boy has bilateral Achilles tendon xanthomas. His father died of an acute MI at 32 years old. Which of the following biochemical defects is most likely responsible for the physical finding in this patient? A - Decreased clearance of VLDL B - Deficient levels of apolipoprotein C-II C - Deficient levels of apolipoprotein E D - Deficient levels of capillary lipoprotein lipase E - Deficient levels of LDL receptors
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angel23 Forum Guru Topics: 83 Posts: 1725	Jan 03, 2008 - 9:27 AM       #2 E)deficient levels of LDL receptors
Ivonne IM PGY-3 Topics: 57 Posts: 1641	Jan 03, 2008 - 9:40 AM       #3 tendinous xanthomas---------> type II a dyslipidemia---------->Deficient levels of LDL receptors--------> E
jean robert Forum Senior Topics: 213 Posts: 966	Jan 03, 2008 - 5:01 PM       #4 E
SmokyWaters Forum Elite Topics: 6 Posts: 432	Jan 05, 2008 - 10:52 AM       #5 eeeeeeeeeya dabba duuu
Tiff Forum Guru Topics: 58 Posts: 597	Jan 05, 2008 - 11:00 AM       #6 The correct answer to the question I posted is E (deficient levels of low-density lipoprotein receptors). Achilles tendon xanthomas are pathognomonic for familial hypercholesterolemia (type II hyperlipoproteinemia) which is inherited in an autosomal dominant fashion. Absent of defective LDL receptors lead to an increase in the level of serum cholesterol, which deposits in the tendon sheaths. Patients die at an early age of an acute myocardial infarcion or stroke.
NNL Awaitin The Unexpected Topics: 779 Posts: 6613	Jan 06, 2008 - 6:23 PM       #7 E - Deficient levels of LDL receptors

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