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crista
Forum Guru Topics: 121 Posts: 402 |
A pt. with mildly compromised renal function is to be given a course of an aminoglycoside drug. In order to calculate the max. dose of the drug that can be given, which of the following measurements would be most helpful? A) BUN and creatinine B) Liver function tests C) Wt. of the patient D) Peak and trough drug levels E) Body surface area of the patient the answer is D and i don;t know why :oops:
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asmi
| Forum Hero Topics: 1049 Posts: 4620
the peak and troughs are nothing but the plasma level changes/oscillations ...seen with intermittent dosing Loading dose = Vd x Cs (where Cs is the desired plasma conc. of the drug)
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peekay
| Forum Guru Topics: 102 Posts: 587
my first guess was BUN and CREATININE LEVELS than i realized peak and trough level is better.i was thinking if kidney fxn is compromised it will show as rise in BUN and CREAT levels.so i need to monitor peak and trough levels so that kidney fxn is not compromised.i hope i am correct very tricky qs indeed.
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bright_nnn
| Forum Senior Topics: 17 Posts: 97
you r right it is a very tricky question.I belive it couldbe BUN and Creatinine.I mean u check the renal function By these tech. But to FIND THE MAX> dose it has to be the peak and Trough levels or the Oscillations in Plasma of Aminoglycoside. How do we calculate the max. dose to be given?? :cry:
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