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 Duchene's Muscular Dystrophy  



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Author6 Posts
  #1

If a girl is diagnosed with Duchene's, how do you think she got it?




  #2

unfavourable lyonization smiling face


  #3

"usmleasr" wrote:
unfavourable lyonization smiling face


can you explain what is it ?


  #4

duchene is a X-linked disorder ..so women are not affected normally...becos they have one normal X chromosome....ie...50%paternal and 50 % maternal are inactivated at random...but it may happen in such a way most of normal X chromosomes are converted to barr body...(unfavourable lyonization..) in which case the female may express the disorder.. 8)


  #5

thanks usmleasr..


  #6

usmleasr,

It seems rare cases of DMD in females are caused by X-chromosome autosome translocation ..resulting in disruption of dystrophin gene..giving rise to female who is heterozygous for DMD gene but phenotypically express the disease ....??





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