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epica |
For step 2 and 1 A 62-year-old man with a 20-year history of alcoholism is admitted to the hospital for treatment of alcoholic hepatitis. He appears disheveled and malnourished. He is 198 cm (6 ft 6 in) tall and weighs 70 kg (155 lb); BMI is 18 kg/m2. Examination shows jaundice and temporal wasting. Scattered rhonchi are heard throughout all lung fields. Cardiac examination shows no abnormalities. Bowel sounds are normal. The liver span is 16 cm. Sensation to pinprick and light touch is decreased over the feet. Deep tendon reflexes are decreased at the ankles. Laboratory studies show: Hematocrit 33% Platelet count 145,000/mm3 Serum Na+ 131 mEq/L Cl– 92 mEq/L K+ 3.1 mEq/L HCO3– 26 mEq/L Mg2+ 0.8 mEq/L Ca2+ 5.8 mg/dL Urea nitrogen (BUN) 6 mg/dL Creatinine 0.8 mg/dL Test of the stool for occult blood is positive. Which of the following is the most likely mechanism of this patient's hypocalcemia? A ) Chronic metabolic acidosis B ) Hypomagnesemia C ) Impaired hydroxylation of vitamin D D ) Primary hyperparathyroidism E ) Renal resistance to parathyroid hormone
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NNL
| Awaitin The Unexpected  Topics: 779 Posts: 6613
B ) Hypomagnesemia >> common in Alcohol Dependence ??
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NNL
| Awaitin The Unexpected Topics: 779 Posts: 6613
C ) Impaired hydroxylation of vitamin D
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epica |
Sorry, B or C?
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NNL
| Awaitin The Unexpected Topics: 779 Posts: 6613
new_n_lost wrote: B ) Hypomagnesemia >> common in Alcohol Dependence ?? 
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epica |
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Ig F
| Forum Guru  Topics: 3 Posts: 500
chronic alcohol intake leads to Hypomagnesemia........but can some1 please explain the mechanism....
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pr20
| Forum Newbie  Topics: 26 Posts: 190
PTH binds to Gs membrane receptor--->activates adenylate cyclase----->generates cAMP--->activates protein kinase A. Magnesium is a cofactor for adenylate cyclase,which generates cAMP(required for PTH action) So hypomagnesemia inhibits PTH activity. It also inhibits synthesis and release of PTH.
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Ig F
| Forum Guru Topics: 3 Posts: 500
thanks pr20....
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