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edie
Forum Guru  Topics: 26 Posts: 1198 |
Just wanted to throw some HY stuff out there. Can you tell me which disease goes with the translocation? a. t(14:18) b. t(8:14) c. t(15:17) d. t(9:22) e. t(11:14)
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yuna
| Forum Senior  Topics: 7 Posts: 229
Thanks Edie, they are so important in the test. edie wrote: Just wanted to throw some HY stuff out there. Can you tell me which disease goes with the translocation? a. t(14:18) b. t(8:14) c. t(15:17) d. t(9:22) e. t(11:14) 1. which one causes activating the tyrosine kinase? 2. Which one has starry sky morphology 3. Which one is due mostly to EBV infection 4. Which one has relationship with retinoic acid 5. Which one has 2 forms of manifestation Some HY facts
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edie
| Forum Guru Topics: 26 Posts: 1198
Thanks for the correlates, Yuna  
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edie
| Forum Guru Topics: 26 Posts: 1198
OK, I'll start, 1. d. t(9:22)--> CML; chr 22 is Philadelphia chromosome. Proto-oncogene is ABL (Goljan calls it "Ah-blah") and it has tyrosine kinase activity.
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keepgoing
| .....  Topics: 109 Posts: 1865
2.t(8:14)-->burkitt's lymphoma-->c-myc oncogene-->LN pattern-->starry sky)-->associated with EBV in 5-15% cases
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yuna
| Forum Senior Topics: 7 Posts: 229
When a pt working as a crew in a construction site, has manifestation of restrictive lung diseases, which one you should ask (sorry I post here cause at beginning I think about mesothelioma...  )A. Brick dust B. Abestos C. Plaster D. Smoking E. Shipyard work
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NNL
| Awaitin The Unexpected  Topics: 779 Posts: 6613
a. t(14:18) >> Follicular Lymphoma BCL overexpression b. t(8:14) >> Burkitt's Lymphoma myc c. t(15:17) >> AML (M3 Acute Promyelocytic) Fusion of RAR gene for Retinoic acid d. t(9:22) >> CML ( 22 is Philadelphia Chromosome) abl translocation e. t(11:14) >> Mantle Cell Lymphoma BCL gene dysregulation.
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edie
| Forum Guru Topics: 26 Posts: 1198
yuna wrote: When a pt working as a crew in a construction site, has manifestation of restrictive lung diseases, which one you should ask (sorry I post here cause at beginning I think about mesothelioma... )A. Brick dust--> bricklayers B. Abestos--> roofers C. Plaster--> construction workers, artisans D. Smoking --> anyone over 50 years with long Hx of smoking? E. Shipyard work--> can also include railworkers? Gross specimen of lung has thick outer layer of tissue like "icing on a cake" --Goljan 
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edie
| Forum Guru Topics: 26 Posts: 1198
NNL, you got em all
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edie
| Forum Guru Topics: 26 Posts: 1198
yuna wrote: 5. Which one has 2 forms of manifestation Would that be Burkitt's--> 1. abdominal and 2. mandibular/craniofacial, the latter unique to Africa?
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mytime
| Go Marching in! Topics: 40 Posts: 3161
Yuna I'd go for B.
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mytime
| Go Marching in! Topics: 40 Posts: 3161
yuna wrote: Thanks Edie, they are so important in the test. 1. which one causes activating the tyrosine kinase? CML 2. Which one has starry sky morphology Burkitt's 3. Which one is due mostly to EBV infection Burkitt's 4. Which one has relationship with retinoic acid M# AML 5. Which one has 2 forms of manifestation U got that EDs! Some HY facts
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mytime
| Go Marching in! Topics: 40 Posts: 3161
EBV- follicular Lymphoma, actually that sud b emore common, i think. Burkitt's
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edie
| Forum Guru Topics: 26 Posts: 1198
Why do we give retinoic acid in M3 AML?
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mytime
| Go Marching in! Topics: 40 Posts: 3161
edie wrote: Why do we give retinoic acid in M3 AML? It induces remission. Gene inolved PML/rar (retinoic acid receptor)alpha.
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mytime
| Go Marching in! Topics: 40 Posts: 3161
edie wrote: Why do we give retinoic acid in M3 AML?
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edie
| Forum Guru Topics: 26 Posts: 1198
Go Mytime!!! Induces remission be inducing maturation of the cells.
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yuna
| Forum Senior Topics: 7 Posts: 229
Great discussion. I wonder why I didn't know this earlier
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edie
| Forum Guru Topics: 26 Posts: 1198
Which tumor suppressor gene is is considered the "guardian of the genome" and why? What multiple-tumor syndrome is associated with this gene?
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yuna
| Forum Senior Topics: 7 Posts: 229
I chose brick dust, thinking of Silicosis, I think I got that wrong
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