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Prep4USMLE » USMLE Step 1 Forum » Microbiology Forum » Comments on 1 THING TO SHARE 1 THING TO ASK


 1 THING TO SHARE 1 THING TO ASK  



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Feyza

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Apr 13, 2007 - 1:07 PM       #1

Kaplan says : main target LIVER for pseudomonas aeruginosa...what does pa got to do with the liver ?!???!?!?

and did u know pasteurella and b.fragilis had capsules too shocked

and also keep in mind that mycobacterium leprae is an OBLIGATE intracellular mo...

details I noticed in my second reading of micro :/ wanted to share just in case u come into nod



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Feyza

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Apr 23, 2007 - 9:23 PM       #2

no comments on the liver stuff ??


monam84

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Apr 23, 2007 - 9:59 PM       #3

how does pa present clinically in the liver? What type of problems does it create in the liver?


GoodGirl

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Apr 24, 2007 - 10:05 AM       #4

Must be a mistake, does not give a sense to me !


Feyza

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Apr 24, 2007 - 11:19 AM       #5

yeaa...I would ignore if it wasnt Kaplan where I read it rolling eyes


NNL

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Apr 24, 2007 - 11:28 AM       #6

In the US: According to data from the Centers for Disease Control and Prevention (CDC) National Nosocomial Infections Surveillance System of 1996, P aeruginosa can be rated as follows:
  • Number 1 cause of intensive care unit (ICU)– related pneumonia
  • Number 1 cause of osteochondritis

  • Number 2-ranked gram-negative organism, responsible for 9% of all nosocomial bacterial and fungal isolates

  • Number 2 cause of nosocomial pneumonia

  • Number 3-ranked isolate in hospital-acquired UTIs

  • Number 4 cause of surgical site infections and of hospital-acquired gram-negative rod bacteremia

  • Number 5 hospital pathogen

  • Number 8-ranked bloodstream isolate

  • Most common bacteria isolated from mild-to-severe form of external otitis and chronic suppurative otitis media

  • Most common gram-negative organism isolated from corneal ulcers and endocarditis

  • Frequent cause of contact lens–associated keratitis

  • Second most frequent cause of brain abscess and meningitis in patients with cancer

  • Third most common cause of recurrent UTIs complicated by obstruction, catheters, or stones

  • Fifth most common cause of recurrent UTIs in schoolchildren



mytime

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Apr 24, 2007 - 11:31 AM       #7

Hey girls liver is primary target coz it's an oxidase positive bug which gets its energy from suger oxidation via electron transport by cytochrome c. JAWETZ.

And btw besides UTI it seems infections by Psuedomonas can be caused everywhere.



bactitech

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Apr 26, 2007 - 7:43 AM       #8

I'm not sure where that liver thing comes from. I can't tell you the last time I saw a Ps. aeruginosa growing in liver tissue. We commonly see them in urines, respiratory specs, and occasional blood cultures. I would say that the list posted by new_n_lost is pretty close to reality.


Feyza

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Apr 26, 2007 - 11:52 AM       #9

ok...I decided to forget about the liver smiling face Ill stick to the info I have ...the ones nnl repeated...thanx guys smiling face


GoodGirl

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Apr 21, 2008 - 6:06 PM       #10

Year later found out about the concept behind the Kaplan sentence : Liver is the primary target for Pseudomonas.

Pseudomonas exotoxin A (PEA) is an extracellular virulence factor produced by the opportunistic human pathogen Pseudomonas aeruginosa. PEA intoxification begins when PEA binds to the low-density lipoprotein receptor-related protein (LRP). The liver is the primary target of systemic PEA, due largely to the high levels of functional LRP expressed by liver cells.

cat.inist.fr/?aModele=affic...fficheN&cpsidt=1033787



taipei817

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Apr 21, 2008 - 6:35 PM       #11

the pseudomona actually does target liver as C. diptheria targets the heart, these 2 have simliar toxins but different targets. i remember reading this from microbiology-rediculous book.


ogv

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Aug 24, 2008 - 8:44 PM       #12

Ps. Aer. exotoxin A is an ADP ribosyl transferase that inhibits EF2 in liver cells.





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