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 L type Ca+2 channels  



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Author3 Posts
  #1

L-type Ca+2 channels of sarcolemma :

a) Large sustained conductance, inactivate fast
b) minimal in cardiovascular system, are responsible for plateau phase of action potential
c) may trigger release of internal Ca+2
d) resistance to Ca+2-channel blockers
e) cardiac L-channels are regulated by ATPase




  #2

c...?


  #3

correct

L-type channels: Large sustained conductance, inactivate slowly, widespread in cardiovascular system, are responsible for plateau phase (slow inward current) of action potential, may trigger release of internal Ca++, sensitive to Ca++-channel blockers, cardiac L-channels are regulated by cAMP-dependent protein kinase (phosphorylation enhances probability of channel opening at a given membrane potential)





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