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Although type 2 diabetes is strongly inherited, the nature of the genetic defect remains unknown in most cases. In those cases where the responsible mutation has been identified, it most frequently involves the gene encoding which one of the following?

A) Insulin

B) Insulin Receptor

C) Glucose transporter

D) Glucokinase

E) Glycogen Synthetase






shaking headshaking head


The Correct Answer is D

The glycolytic enzyme glucokinase plays an important role in the regulation of insulin secretion and recent studies have shown that mutations in the human glucokinase gene are a common cause of an autosomal dominant form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM) that has an onset often during childhood.


neat stuff! never new that.


shockedshockedneither did i.nod


Type 1 is Insulin receptor defect as I read in the Qbank Kaplan question..

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