Prep for USMLEPrep for USMLE
         Forum      |     Resources New Posts   |   Register   |   Login

 Genetics 1  

Post Reply  
  • 0/5
  • 1
  • 2
  • 3
  • 4
  • 5

Author5 Posts

Mutations in which of the following genes when inherited in the germline are least likely to be associated with the development of breast cancer?

A. ATM gene
B. bcl-2 gene
C. BRCA 1 gene
D. BRCA 2 gene
E. p53 gene




raised eyebrow





BRCA 1 & BRCA 2 cause early breast cancer (dominant inheritance). ATM gene causes breast cancer ��" DNA repair disorder (recessive inheritance). P53 mutations are found in ~60% of all human cancer types including breast. Note Li-Frumeni syndrome ��" vulnerable to a wide range of cancers, 50% likelihood of Ca by age 30 & 90% by age 65. The precise function of p53 is unknown ��" may act as DNA policeman to prevent transcription & replication of unstable DNA.

Bcl-2 is involved in the control of apoptosis (programmed cell death) & prevents the p53 mediated destruction of cells with damaged DNA. It also may prevent the death of cells severely damaged by chemotherapy, & mediates drug resistance & contributes to neoplasia by this mechanism rather than promoting aberrant cell growth. It was first identified because of an association with follicular lymphoma.

Bookmark and Share

This thread is closed, so you cannot post a reply.

Login or Register to post messages

show Similar forum topics

Genetics, genetics, to be or not to be!
Genetics Non-profit Organization
show Related resources

Biochemistry & Genetics: PreTest Self-Assessment & Review
Medical Genetics
Elsevier's Integrated Genetics

Advertise | Support | Premium | Contact