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Spinobulbar muscular atrophy is an X linked recessive motor neuron disease, arising from a mutation in the androgen receptor gene. The normal allele of the gene has 10 ajacent glutamine codons(CAG) in exon 1, whereas the diseased allel has 40 of these CAG repeats in the same region.

The most appropriate DNA based test to detect this mutation would utilize PCR primers:
a) complementary to the CAG repeat followed by a Southern blot using a CAG repeat specific DNA probe.
C)flanking the CAG repeat followed by a southern blot using a CAG repeat specific DNA probe.
the answer is c

Would you explain to me what is "flanking the CAG mean"?Does it mean GAC?

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