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The most common clinical consequence(s) of C3 deficiency is (are)

A) increased incidence of tumors
B) increased susceptibility to viral infections
C) increased susceptibility to fungal infections
D) increased susceptibility to bacterial infections
E) all of the above






D C3 deficiencies are clinically most severe and are often associated with immune complex disease and susceptibility to recurrent bacterial infections. This is due to the fact that C3 plays a central role in activation of C5 and formation of MAC and is important for both classical and alternative pathway. C3 plays a critical role in converting a humoral antibody response in to an effective host defense mechanism. Products of C3 or opsonic fragments of C3 have receptors on various cells which help in phagocytosis of opsonized pathogens.



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