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 Hemato  



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Author4 Posts
  #1

... Aplastic anemia ...

1- what are the diagnostic criteria for aplastic anemia?

2- what is the treatment of choice? for patients >40 years? for <40 years?

3- what are the most common causes ?

4- common side effects of the drugs used for tx of this dz?





  #2

1. Dx of Aplastic Anemia: Pancytopenia + Hypocellular (< 25% hematopoetic cells) fatty bone marrow biopsy.

2. Tx of choice: <40 y/o is bone marrow transplantation; >40 yrs or lacks suitable donor - Immunosuppression with a combination of antilymphocyte globulin (ALG)/antithymocyte globulin (ATG) & Cyclosporine.

4. Common side effects: ALG/ATG - Serum sickness, anaphylaxis (rare); Cyclosporine - nephrotoxicity, hypertension, seizures, oppertunistic infections (esp. Pneumocystis carinii - prophylax with pentamidine); Combination Tx - Myelodysplasia, Leukemia







  #3

good



  #4

and the most common causes are:

idiopathic in 40-70% of pts.

then: drugs such as chloramphenicol, benzene, phenylbutazone, sulfonamides, gold;

paroxysmal nocturnal hemoglobinuria

and infections.






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