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 discrepancy  



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  #1

carrier rate for CF is 1/25
what is the incidence of the disease?

Ans: according to kaplan : 1/25 * 1/25
accor to goljan : 1/25 * 1/25 * 1/4

what is the truth?





  #2

carrier means (HE equilibrium) 2pq = 1/25; p=1 for rare disease ---q=1/50. for AR disease have to be homozigot to have the disease so incidence= q2 ------1/2500.





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