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Prep4USMLE » USMLE Step 1 Forum » Pathology Forum » Comments on pernicious anemia


 pernicious anemia  



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peekay

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Feb 07, 2004 - 3:24 PM       #1

most common antibody associated with PA.
true or false------ vit B12 def causes PA
PA is associated with chronic atrophic gastritis and hence there is increased risk of gastiric ca.(true or false)


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asmi

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Feb 07, 2004 - 6:56 PM       #2

pernicious anemia is a cause of B12 deficiency.
And yes ,atrophic gastritis predisposes to adenocarcinoma of stomach.


Idiopathic

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Feb 07, 2004 - 8:04 PM       #3

The Ab in PA is anti-intrinsic factor.


peekay

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Feb 08, 2004 - 1:15 PM       #4

there are three abs in PA patients: 75 % have blocking ab,50 % have binding abs and 90% have canalicur abs which is on gastric prietal cells
for more detail please refer to robbins patho( megaloblastic anemia section)
I thought this might be a usmle type qs.sinc they like to ask qs which give us this feeling that we know the topic but but want us to know even deeper


asmi

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Feb 08, 2004 - 1:33 PM       #5

thanks for telling us about diff.antibodies





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