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 splenic sequestration  

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hi, what's the difference between splenic sequestration and splenic infarction in sickle cell disease? both are caused by blocking the vessels in spleen, right? difference?


splenic sequestration is caused by intrasplenic trapping of rbcs causing a precipitous fall in hb level and potential for hypovolemic shock.

splenic infarction is necrosis in the spleen due to interrupt of blood flow (vascular occlusion).


most sicklers have infarcted their spleen and it undergoes autosplenectomy by the time they are 6 years old. that is why they are at risk of infections with encapsulated organisms after that, coz they no longer have a functioning spleen.

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