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docswapna Forum Elite Topics: 61 Posts: 228	Sep 26, 2006 - 3:23 PM       #1 Family with father ,grandfather and grandmother suffering from gardner's syndrome.father has 4 children.what are the chances that atleast one child has inherited the gardner's syndrome allele? A.1/4 B.1/2 C.3/4 D.13/16 E.15/16
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fox Forum Guru Topics: 70 Posts: 720	Sep 26, 2006 - 3:42 PM       #2 U had posted a similar q (wardenburg's). We lesser mortals got stumped. Could u tell us watz the answer for both the Q?
docswapna Forum Elite Topics: 61 Posts: 228	Sep 26, 2006 - 6:05 PM       #3 for wardenbugs ur right. 1/8 1/2x1/2x1/2 try this. i will post the ans later..
alexaE Forum Elite Topics: 23 Posts: 328	Sep 26, 2006 - 10:59 PM       #4 here it is E
Topics: Posts:	Oct 09, 2006 - 1:26 AM       #5 E
Palaniappan Forum Senior Topics: 30 Posts: 148	Nov 20, 2006 - 1:41 PM       #6 Can anyone exlain the answer E?
nrkmani Forum Newbie Topics: 0 Posts: 3	Nov 23, 2006 - 10:30 PM       #7 gardener is autosomal dominant. 1 st genereration risk is 50% 2 nd gen risk is 25% (1/4) total probability of all 4 children affected is 1/4 *1/4*1/4*1/4 =1/16 probability of atleast one child affected=1-1/16=15/16
drbin Forum Guru Topics: 27 Posts: 554	Dec 01, 2006 - 7:51 PM       #8 hw could the risk in first gen be 50 % bs both grandfather and gr mother affected, so chance must be 75%
drbin Forum Guru Topics: 27 Posts: 554	Dec 01, 2006 - 8:03 PM       #9 Ans E? 1st gen Aa * Aa AA Aa Aa aa So chance that father has diseased allele is 3/4 2nd gen Aa * aa Aa Aa aa aa so risk is 50 % ie 1/2 chance for all 4 to be affected is 1/2 * 1/2 * 1/2 * 1/2 = 1/16 Risk of atleast 1 having disease allele = 1-1/16= 15/16

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