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Family with father ,grandfather and grandmother suffering from gardner's syndrome.father has 4 children.what are the chances that atleast one child has inherited the gardner's syndrome allele?
U had posted a similar q (wardenburg's). We lesser mortals got stumped. Could u tell us watz the answer for both the Q?
for wardenbugs ur right. 1/8
try this. i will post the ans later..
here it is E
Can anyone exlain the answer E?
gardener is autosomal dominant.
1 st genereration risk is 50%
2 nd gen risk is 25% (1/4)
total probability of all 4 children affected is 1/4 *1/4*1/4*1/4 =1/16
probability of atleast one child affected=1-1/16=15/16
hw could the risk in first gen be 50 % bs both grandfather and gr mother affected, so chance must be 75%
Aa * Aa
AA Aa Aa aa
So chance that father has diseased allele is 3/4
Aa * aa
Aa Aa aa aa
so risk is 50 % ie 1/2
chance for all 4 to be affected is 1/2 * 1/2 * 1/2 * 1/2 = 1/16
Risk of atleast 1 having disease allele = 1-1/16= 15/16
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