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Might anyone be able to elucidate how lactic acidosis in excessive physical exertion might lead to the vomiting response often seen as a result of unregulated anaerobic respiration. I am assuming the vomiting response is a result of the hyperlacatemia, but it may be a completely different pathway.
This is not that common because lactate is regulated via the Cori cycle in the liver to form more glucose.
During intense exercise lactate accumulates in the muscle decreasing Ph potentially causing cramps. Much of this diffuses into the blood stream.
Should vomiting occur from lactic acidosis its probably the result of the vomiting center being stimuated by the chemoreceptor trigger zone in the fourth ventricle
hope this helps
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