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 Down's syndrome  

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What is triple screen (for diagnosis of down's syndrome) ?


Triple screen tests for: beta HCG, placental estrogen, and alphat-fetoprotein. It will be positive in cases of neural tube defects (anencephaly, spina bifida) or in some chromosome abnormalities (Down's)

High AFP correlates with a neural tube defect
High estrogen and beta HCG but low AFP indicate possible chromosome abnoramlity.

The test is about 50% specific, and an amniocentesis is the test of choice for the confirmatory chromosome test, while I believe ultrasound tests for the neural tube defects.


yes right.
Thanks idopathic smiling face

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