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 SIADH  



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Author12 Posts
  #1

does anyone know causes of SIADH other than...
1. small cell carcinoma of the lung
2. oral sulfonylureas( specially 1st generation) :?:




  #2

drugs: morphine, oxytocin,chlorpropamide.

lung infections: T.B.

CNS disorders: tumor, infection


  #3

Also pneumonia and pancreas ca


  #4

thanks alice
i think we have completed the list


  #5

hey asmi so all these cause SIADH? :?:


  #6

Elevated TSH (primary hypothyroidism) can cause hyponatremia due to siADH, although siADH does not HAVE To be present.

(TSH mildly stimulates ADH release)


  #7

Aso Hodkin's disease.


  #8

in drugs, carbamazepine also causes SIADH


  #9

Increased Hypothalmic Production of ADH
1. Neuropsychiatric disorders
1. Infections: meningitis, encephalitis, brain abscess
2. Vascular: thrombosis, subarachnoid or subdural hemorrhage, temporal arteritis, cavernous sinus thrombosis, stroke
3. Neoplasm: primary or metastatic
4. Skull fracture, traumatic brain injury
5. Psychosis, delirium tremens
6. Other: Guillain-Barré syndrome, acute intermittent porphyria, autonomic neuropathy, postpituitary surgery, multiple sclerosis, epilepsy, hydrocephalus, lupus erythematosus.
2. Drugs
1. Intravenous cyclophosphamide
2. Carbamazepine
3. Vincristine or vinblastine
4. Thiothixene
5. Thioridazine, other phenothiazines
6. Haloperidol
7. Amitriptyline, other tricyclic antidepressants or serotonin-reuptake inhibitors
8. Monoamine oxidase inhibitors
9. Bromocriptine
10. Lorcainide
11. Clofibrate
12. General anesthesia
13. Narcotics, opiate derivatives
14. Nicotine
3. Lung diseases and interventions
1. Pneumonia
2. Tuberculosis
3. Lung abscess, empyema
4. Acute respiratory failure
5. Positive pressure ventilation
4. Perioperative Period - associated with the stress response to injury and pain
Ectopic (nonhypothalamic) production of ADH
1. Cancer: Small cell carcinoma of lung (2/3 of patients with small cell have impaired water excretion), bronchogenic, duodenum, pancreas, thymus, olfactory neuroblastoma, bladder, prostate, uterus
2. Lymphosarcoma, reticulum cell sarcoma, mesothelioma, Ewing sarcoma
3. Hodgkin's disease, leukemia
4. Pulmonary tuberculosis
Potentiation of ADH effect
1. Chlorpropamide
2. Carbamazepine
3. Psychosis
4. Intravenous cyclophosphamide
5. Tolbutamide
6. Prostaglandin-synthesis inhibitors (salicylates, NSAIDS)
Exogenous administration of ADH
A. Vasopressin, desmopressin
B. Oxytocin

is that enough?
:roll:


  #10

:shock: :shock:
could u please quote a source for this looooong interesting list?


  #11

i don't know all of this but know some mechanism.
do u know all this mechanism?
i copy from one website.
don't know all mechanism accept some drugs and hypothalams mechnisms. :roll:


  #12

some of them mechanisms r also in the kaplan as well and some in medicine book. :?





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