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khorshid Forum Guru Topics: 32 Posts: 591	Jul 20, 2006 - 6:22 PM       #1 in Wiskott-Aldrich syn why do we have thrombocytopenia ? (what defect causes it?)
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tolito Forum Junior Topics: 119 Posts: 2136	Jul 20, 2006 - 7:22 PM       #2 there is a genetic defect in the formation of actin of the cytoskeleton. i dont understand the details well. the defect results in abnormal growth, endocytosis, cytokinesis and exocytosis
khorshid Forum Guru Topics: 32 Posts: 591	Jul 20, 2006 - 7:46 PM       #3 as far as I've understood the platelets lack CD43( membrane sialophorin), and splenectomy corrects their thromboctypenia but not other problems.
tolito Forum Junior Topics: 119 Posts: 2136	Jul 20, 2006 - 9:40 PM       #4 so we put our knowledge together. the gene responsible for the cytoskeleton is said to be responsible for the lack of CD43 which is present on the villi. if you are interested, check this link http://www.emedicine.com/med/topic1162.htm
khorshid Forum Guru Topics: 32 Posts: 591	Jul 21, 2006 - 2:37 AM       #5 thanks tolito for the link

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