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 diuretic to treat diabetes insipidus????  

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can anyone explain.........whats the rationalization behind using thiazide diuretic to treat diabetes insipidus(ADH resistance)?


INTRAVASUCLAR volume contraction increases ADH secretion,overriding the effect of hyposmolarity


thanks mjl......
but ,how does that help the patient as the increase in ADH wont do anything coz in this condition the collecting ducts are unresponsive to ADH....... :?


you are right -HYDRATION (ADH does nothing)

**Thiazide decreases urine flow by inhibiting sodium reabsorption in distal tubule**This lowers free water production and, by causing extracelular volume contraction,increases proximal salt and water reabsorption,reducing delivery to the distal nephron. :idea:


thanks mjl!!! grin

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