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 diuretic to treat diabetes insipidus????  



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Author5 Posts
  #1

can anyone explain.........whats the rationalization behind using thiazide diuretic to treat diabetes insipidus(ADH resistance)?




  #2

INTRAVASUCLAR volume contraction increases ADH secretion,overriding the effect of hyposmolarity


  #3

thanks mjl......
but ,how does that help the patient as the increase in ADH wont do anything coz in this condition the collecting ducts are unresponsive to ADH....... :?


  #4

you are right -HYDRATION (ADH does nothing)

**Thiazide decreases urine flow by inhibiting sodium reabsorption in distal tubule**This lowers free water production and, by causing extracelular volume contraction,increases proximal salt and water reabsorption,reducing delivery to the distal nephron. :idea:


  #5

:idea:
thanks mjl!!! grin





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