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 Type II Hypersensitivity  

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Can anyone describe Type II hypersensitivity in detail and give 7 diseases?


Type II hypersensitivity or antibody mediated hypersensi... is
*Mediated by IgG or IgM antibodies against tissue antigens.
*antibody binds to cells or tissues and causes local complement activation,influx of leuckocytes,tissue destruction because of ADCC,degranulation by phagocytes,oxygen radicals.
*results in organ specific antibody production
*effector cells are PMN,Macrophages,NK cell
*Examples: hemolytic disease of newborn.
Graves disease
myasthenia gravis
goodpasture syndrome
autoimmune hemolytic anemia
autoimmune thrombocytopenic purpura
hyperacute graft rejection
rheumatic fever
transfusion reactions


Examples of cell injury in which antibody reacts with antigenic components of a cell are
Coombs'-positive hemolytic anemias,
antibody-induced thrombocytopenic purpura,
Goodpasture's syndrome,
pernicious anemia.
multisystem hypersensitivity diseases (eg, SLE).


Also Type II works on the surface
I always see SLE as TYPE III!!!


What does works on surface means?


Cytotoxicity occurs when antibody is directed aginst epitopes that occur on the SURFACE membrane of host cells

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