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 Type II Hypersensitivity  



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Author6 Posts
  #1

Can anyone describe Type II hypersensitivity in detail and give 7 diseases?




  #2

Type II hypersensitivity or antibody mediated hypersensi... is
*Mediated by IgG or IgM antibodies against tissue antigens.
*antibody binds to cells or tissues and causes local complement activation,influx of leuckocytes,tissue destruction because of ADCC,degranulation by phagocytes,oxygen radicals.
*results in organ specific antibody production
*effector cells are PMN,Macrophages,NK cell
*Examples: hemolytic disease of newborn.
Graves disease
myasthenia gravis
goodpasture syndrome
autoimmune hemolytic anemia
autoimmune thrombocytopenic purpura
hyperacute graft rejection
rheumatic fever
transfusion reactions


  #3

Examples of cell injury in which antibody reacts with antigenic components of a cell are
Coombs'-positive hemolytic anemias,
antibody-induced thrombocytopenic purpura,
leukopenia,
pemphigus,
pemphigoid,
Goodpasture's syndrome,
pernicious anemia.
multisystem hypersensitivity diseases (eg, SLE).


  #4

Also Type II works on the surface
I always see SLE as TYPE III!!!


  #5

What does works on surface means?


  #6

Cytotoxicity occurs when antibody is directed aginst epitopes that occur on the SURFACE membrane of host cells





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