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robin082006 Forum Hero Topics: 468 Posts: 5028	Apr 23, 2006 - 2:59 PM       #1 402. Gardner's syndrome is an autosomal dominant condition characterized by multiple polyps of the intestines, bony tumors, skin cysts, and a high risk of intestinal cancer. A family is encountered in which a greatgrandfather,grandmother, and father are affected with Gardner's syndrome and develop intestinal cancer in their thirties. The father brags that none of his four children have inherited Gardner's syndrome because they lack skin cysts and have not had cancer. The chance that at least one child has inherited the Gardner's syndrome allele, and the reason the children have not manifested cancer, are a. 1/4, ascertainment bias b. 1/2, variable cancer predisposition c. 3/4, early-onset disease manifestation d. 13/16, incomplete medical evaluation e. 15/16, later-onset disease manifestation
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ralux Forum Junior Topics: 5 Posts: 58	Apr 26, 2006 - 11:04 PM       #2 b
robin082006 Forum Hero Topics: 468 Posts: 5028	Apr 26, 2006 - 11:13 PM       #3 try again
vanshita Forum Guru Topics: 33 Posts: 950	Apr 28, 2006 - 3:28 AM       #4 A?
robin082006 Forum Hero Topics: 468 Posts: 5028	Apr 28, 2006 - 7:01 AM       #5 answer is E all children have no disease=1/2*1/2*1/2*1/2=1/16 At least one child has disease=1-1/16=15/16
robin082006 Forum Hero Topics: 468 Posts: 5028	Apr 28, 2006 - 7:01 AM       #6 answer is E all children have no disease=1/2*1/2*1/2*1/2=1/16 At least one child has disease=1-1/16=15/16
Rana Khan Forum Senior Topics: 28 Posts: 181	May 04, 2006 - 5:15 PM       #7 e
sridevibandaru24 Forum Guru Topics: 33 Posts: 429	Jun 25, 2006 - 12:45 PM       #8 Robin! i am unable to understand the concept. i do not understand why u multiplied1/2*1/2*1/2*1/2. how u got 1/2 for each person? please explain. thanks
robin082006 Forum Hero Topics: 468 Posts: 5028	Jun 25, 2006 - 1:03 PM       #9 Yes, each child has 1/2 chance to be free of disease and 1/2 chance to have disease.
Cedrick Life Topics: 0 Posts: 1425	Jun 25, 2006 - 1:06 PM       #10 Good math good question too Thanks 15/16 later onset disease manifestation
vallia Forum Guru Topics: 96 Posts: 884	Jul 03, 2006 - 12:41 AM       #11 yes, good calculation, 4 generations, autosomal dominant condition

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