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 NB F3 S1 Compliment Therapy for 5 FU  



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Author7 Posts
  #1

A 59 year old man comes to the ER because of fever, shaking chills for 24 hours. he completed a course of fluorouracil for a neoplasm one week ago. His temparature is 39C and BP 85/60. His HCT 30% , leukocyte count 400/mm3, platelet count 100,000 mm3. which of the following agents will most specifically complement anibiotic therapy in this patient.

a) Erythropoietin

b) GMCSF

c) IL-1

d) IL-2

e) Leucovorin.





  #2

b. GMCSF


  #3

explain plzzzzzzzz


  #4

GMCSF: (granulocyte-macrophage colony-stimulating factor) is indicated in bome marrow insufficiency caused by anti neoplasm therapy.



Coipied:
GMCSF has a central role in proliferation and differentiation of hematopoetic cells. Furthermore, it influences the proliferation and migration of endothelial cells. GMCSF elicits these functions by activating a receptor consisting of a ligand-specific -chain and a -chain, which is common for GMCSF, IL-3 and IL-5. It is known that various signaling molecules such as Janus kinase 2 or transcription factors of the STAT family bind to the common -chain and initiate signaling cascades. However, -chain specific signal transduction adapters have to be postulated given that IL-3, IL-5 and GMCSF induce partly distinct biological responses. Using a yeast two-hybrid system, we identified the -chain of the GMCSF receptor as putative interaction partner of IB kinase , one of the central signaling kinases activating the transcription factor NF-B. Using endogenous protein levels of endothelial cell extracts, we could verify the interaction by co-immunoprecipitation experiments. Fluorescence resonance energy transfer (FRET) microscopy confirmed the direct interaction of CFP-IKK and YFP-GMR in living cells. Functional studies demonstrated GMCSF-dependent activation of IB kinase activity in endothelial cells, degradation of IB and activation of NF-B. Further biological studies using GMCSF-dependent TF-1 cells indicated that GMCSF-triggered activation of NF-B is important for cell survival and proliferation.

Website: http://www.bloodjournal.org/cgi/content/short/200...




  #5

well GM-CSF won't overcome the deficiency of hemoglobin, wht about that?


  #6

yes ssrpk, dats true. but in the above choices GM-CSF is the better one.


  #7

I first went for A, but your choice seems best now





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