Prep for USMLEPrep for USMLE
         Forum      |     Resources New Posts   |   Register   |   Login

 About ANCA  

Post Reply  
  • 0/5
  • 1
  • 2
  • 3
  • 4
  • 5

Author2 Posts

what are the conditions that ANCA appear in?
what does the C-ANCA & P-ANCA (perinuclear)pattern of the antibodies indicate?


Antineutrophilic Cytoplasmic antibodies are antibodies that bind to certain cytoplasmic substances in neutrophiles. After a certain preparation(like centrifuge), neutrophils are tested with patient's serum antibodies to see if the antibodies are present in the patient.
C-ANCA (Cytoplasmic) are antibodies to Proteinase 3 Antigen, very strongly associated with Wegener's granulomatosis. also seen to an extent in Cresentic glomerulonephritis and Polyarteritis nodosa.
P-ANCA(Perinuclear) are antibodies to Myeloperoxidase and seen commonly in Cresentic glomerulonephritis and Polyarteritis nodosa.

a way to remember this might be P for Polyarteritis, the other one Wegener. Cresentic glomerulo can have both but more of P.

Bookmark and Share

This thread is closed, so you cannot post a reply.

Login or Register to post messages

show Similar forum topics

understanding P-ANCA & C-ANCA
? ANCA in Polyarteritis nodosa
show Related resources

Advertise | Support | Premium | Contact