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 ADH release  

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would you please explain me this?

atrial natriuretic peptide inhibits ADH release :increased ANP does not override stimulus for ADH release by increased POsm or volume depletion.


Atrial natriuretic peptide (ANP, ANF) is synthesized, stored, and released atrial by myocytes in response to atrial distension, angiotensin II stimulation, endothelin, and sympathetic stimulation (beta-adrenoceptor mediated). Therefore, elevated levels of ANP are found during hypervolemia and congestive heart failure. It inhibits ADH to correct the volume load.
I think the second segment of the statement means that as ANP increases, if this goes to volume depletion and high Osm then inspite of ANP being high, ADH will increase. In short, volume depletion and high osm are more potent to control ADH than ANP.
Hope this helps smiling face



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