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 Type II and Type II hypersensitivity  

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Can anyone explain the difference between type II and Type III hypersensitivity. and name 10 diseases associateed with Type III hypersensitivity??


type II where antibody binds to surface, membrane or some receptor and ativates complement

type III where free antigen-antibody complexes are accumulated and then fix complement !


Examples of Type 3 HS reaction:

a. certain drug allergies

b.blood transfusion reactions

c. hemolytic dse. of newborn

d.goodpasture's syndrome w/ antiglomerular b.m. ab formation.

examples of type 3 hypersensitivity rxn.

a. serum sickness


c. immune complex GN




Type III dz's: also:

rheumatic fever, polyarteritis nodosa, Rheumatoid arthritis (ar"three"tis)

There is a nice list in the lecture notes for kaplan in the immuno section of the micro book.


rheumatic fever is type II, rheumatogenic M proteins of strp.pyogenes cross reacts with joint tissues and myocardium!


i mean the antibodies againsts those M proteins cross-reacts !


You might be right, I don't know why I have it written in my notes as type III, but it is an antibody cross reacting to the cardiac antigens, so it must be type II not III. Thanks for the correction !


he is right!!

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