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cell swell....

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openup05

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May 03, 2005 - 8:49 PM

45 year old women has an acute cornary occlusion. Within seconds the ischemic regoin shows mitochondrial swelling and depletion of glycogen granules. Which of the following metabolic events is the most likely cause of these cellular changes ?

A.INflux of Na
B.Efflux of K
C.ATP depletion
D.Accumulation of free fatty acid
E.Degradation of membran phospholipids

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ssrpk

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May 04, 2005 - 12:37 AM

C.ATP depletion

SDK

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May 04, 2005 - 4:56 AM

I agree with ssrpk..... 8)

lucky1

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May 04, 2005 - 6:31 PM

hi
can u please explain why cell swells as ATP depletes.
i was thinking that it was Na influx

SDK

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May 04, 2005 - 11:26 PM

As ATP deplete it leads to---dec: Na-K atpase----influx of Na & efflux of K------cell swell..(basically due to depletion of ATP).....
In this there is mitochondrial swelling due to formation of mitochondrial permeablity transition due to inc: Ca which activate PLase..
Inc: Ca occur due to dec: ATP(dec: oxidative phosphorylation) by membrane damage....

ssrpk

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May 05, 2005 - 1:59 AM

hey SDK ..... is this mtichondrial permiability transition a part of reversible injury????? or irreversible!

SDK

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May 06, 2005 - 12:10 AM

It is an irrevrsible process.......
This will furthur supress oxidative phosphorylation & worse cell injury process.......... 8)

ssrpk

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May 06, 2005 - 1:25 AM

thnx 8)