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pawan.doc Forum Newbie Topics: 2 Posts: 14	Apr 27, 2005 - 8:20 AM       #1 can anybody explain to me d mechanism of hypocalcemic tetany?i know it causes increased excitability of d nerve fibers.but how?
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ssrpk Forum Junior Topics: 154 Posts: 2850	Apr 27, 2005 - 9:09 AM       #2 it's just a speculation tht Ca++ binds to the extrecellular component of voltage gated Na+ channels and modulate it's responsiveness! thereby dec. Ca++ levels will lead to enhanced sensitivity to incoming stimuli.
dariush Forum Elite Topics: 20 Posts: 353	Apr 27, 2005 - 9:19 AM       #3 as you know Skl. muscles are not dep. on EC Ca++. they use their own sarcoplasmic depot. i think hypo-Ca simply decreases the threshold for depolarization at the endplates similar to the axons which leads to more frequent EPAPs which cuase tetany.
pawan.doc Forum Newbie Topics: 2 Posts: 14	Apr 28, 2005 - 7:53 AM       #4 hey! tht aint convincin enough.someone help me out!darius r u sure?
SDK Forum Fanatic Topics: 537 Posts: 1586	Apr 29, 2005 - 9:26 PM       #5 ssrpk is rite.... Ca+ compete for Na. If Ca level is rise it compete for Na & cause dec: excitibility of neurons.. & If Ca level dec: then there is inc: sensitivity to Na+......Tetany.

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