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 Acetocholine  



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Author8 Posts
  #1

why acetocholine has a negative inotropic effect on atria




  #2

muscarinic receptor stimulation at SA node --dec hrt rate-neg inotropy


  #3

Major parasympathetic neurotransmitter think-rest and digest.
But I agree with K.


  #4

inotropic means contractility
Ach ----dec. HR throug Muscrinic R. at SAN----- -ve chronotropic
however, Ach decrease contractility by decreasing intracellular calcium
throug decreasing ca influx during plateu phase....."only in Atria"----- -ve
inotropic


  #5

presynaptic inhibition of sympathetic nerve terminals in the ventricles


  #6

Plz ssrpk tell me....
How does Ach make presynaptic inhibition of the Sympathetic N terminal to ventricle??????? :?:


  #7

M2 receptors coupled to Gi protein, however they are predominantly present in the atria but some wht also present in small amounts in the ventricles whihc probably only limits sympathetiuc activity!

however with PANS it;s -ve chronotropism tht is more important!


  #8

Mmmmmm,,,,Thanks ssrpk





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