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phuluong2k Forum Newbie Topics: 715 Posts: 2008	Mar 14, 2005 - 3:17 PM       #1 During a marathon, a 28-year-old woman initially has pain and distress but suddenly feels exhilaration about halfway through the race. The best explanation is most likely to be increased release of A) ACTH B) β-endorphin C) epinephrine D) glucagon E) somatostatin Any one can answer ? I think of epinephrine, but not very clear
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mjl1717 Forum Junior Topics: 964 Posts: 5442	Mar 14, 2005 - 4:00 PM       #2 B-endorphin-usually at delta and mu receptors.
Natasha Forum Newbie Topics: 0 Posts: 1	Mar 26, 2005 - 10:22 AM       #3 It is beta endorphin -sure.
phuluong2k Forum Newbie Topics: 715 Posts: 2008	Mar 27, 2005 - 1:14 AM       #4 Hey, so can you explain the mechanism of this
mjl1717 Forum Junior Topics: 964 Posts: 5442	Mar 27, 2005 - 9:30 AM       #5 Opiate like( responsible for "the rush" or "natural High" ironically also in the GI tract [mu & delta receptors] I believe the parent compound is Proopiomelancorticotropin.
phuluong2k Forum Newbie Topics: 715 Posts: 2008	Mar 29, 2005 - 4:50 AM       #6 Ok, thanks
hgheith Forum Senior Topics: 56 Posts: 541	Mar 31, 2005 - 8:38 PM       #7 Exercise is a form of stress on the body, it promotes the release of CRH, this hormone acts on the anterior pituitary to release POMC (pro-opiomelanocortin) this splits into ACTH and beta-lipotropin. part of the beta lipotropin is the endorphins (or endogenous morphine) which gives that natural "high". The goal of this mechanism is to release cortisol to help mobilize energy stores for the body's increased need. hope that helps

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