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Why does a pulmonary embolism leads to inc. A-a gradient....? Va/Q mismatch occurs(>0.8) ... but still there is no shunt effect so why does PaO2 decrease, if ventilation is normal?


because an emboli occupies part if not all the diameter of the blood vessel, thus increasing the oxygenation time of the blood going throught that vessel. so the blood coming from this vessel is <100% saturated, leading to inc A-a gradient.

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