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 A 65-year-old male has noticed increasin  

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A 65-year-old male has noticed increasing fatigue, anorexia, and abdominal and bone pain over the last several months. His family has noted increased dyspnea with the things he used to do with ease and some level of confusion with slurred speech. The patient goes to see his doctor. After looking at his lab results, the physician sends him immediately to a hematologist/oncologist, who confirms his diagnosis of chronic myelogenous leukemia (CML). Further workup is done and the patient is placed on hydroxyurea. Which of the following best describes the method by which hydroxyurea will help this patient?

A. 5-Fluorouracil inhibits thymidylate synthase and prevents cell progression in the S phase

B. Hydroxyurea inhibits ribonucleotide reductase and prevents the formation of dNTPs for DNA synthesis

C. Hydroxyurea inhibits thymidylate synthase, thereby stopping cell progression in the M phase

D. Hydroxyurea stimulates thymidylate synthase, thereby accelerating the progression of apoptosis

E. Hydroxyurea and 5-fluorouracil both inhibit thymidylate synthase, thereby inhibiting the S phase


Answer-b --(Its a urea analogue)


right again grin grin grin

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