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 hemato..easy one  



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Author6 Posts
  #1

how would a pathologist distinquish a peripheral blood smear between a patient with G6PD def and pyruvate kinase def ?




  #2

G6PD def(HEINZ BODIES PRESENT)

pyruvate kinase def (NO HEINZ BODIES)


  #3

correct smiling face


  #4

also bite cells....present in G6PD def.


  #5

G6PD deficiency:
1) HEINZ BODY --> Screening test during active hemolysis
2)RBC enz analysis-->Confirmatory test when hemolysis has subsided
3)Peripheral Blood-->bite cells,reticulocytosis

Pyruvate kinase deficiency:
1)Confirmatory Test-->RBC enz assay.
2)Reticulocytosis,RBCs with Thorny projections.


  #6

Over here, an enzymatic test is used as the screening test. Those with G6PD deficiency will fail to oxidize the dye (no colour change).

Echinocytes are seen in PK deficiency.





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