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 CYSTIC FIBROSIS INCREASED VISCOS.  



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Author6 Posts
  #1

ı used to think the reason for increasing viscosity of secretions in CF that it was about Chloride imbalance. But ı read in my IM book the exact reason is not that. :o guess what :idea:




  #2

i've been amazed by how many different theories there are for one of the earliest cloned disease genes. i thought the current one is that cftr normally inhibits basolat na pump, so in cf mucus is "dried" by h2o following na out of the lumen. what did you read?


  #3

every thing about this mechanism is a theory and they dont test such things on exam


  #4

goljan actually talks about this in his lecture, but i can't remember it. i need to go back next wk and listen to what he said. i think he talks about it in sweat glands and in the resp. tract.


  #5

Inadequate hydration of trcaheobranchial epithelium imparies mucociliary clearence.High concentrations of DNA in airway secretions ( due to chronic airway inflammation and autolysis of neutrophils ) increase sputum viscosity. CMDT 2004 page: 239.


  #6

and that's why we use recombinant human Deoxyribonuclease in treatment. ( rhDNase).. :idea:





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