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 Renal pysio Q  

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How does hyperosmolarity lead to pottasium shift out of the cell?


When there is hyperosmolarity this causes cell shrinkage, so K+ is forced out of the cell therefore causing hyperkalemia. I'm sure there is probably a better answer for this but this is what makes sense for me. And this logic also explains the opposite - hypo-osmolarity causes cell swelling --- more room in cell to uptake K+... therefore causes Hypokalemia.


What was the status of patient?
Diabetic ketoaidosis? or HONK?


IMHO hyperosmolarity itself wont make K+ to come out of cell, but hyperosmolar condition may cause acidosis which may activate H+/K+ ion exchange pump and in exchange for H+ , there may be shift of K+ out of cell.

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