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 q of physio  



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Author7 Posts
  #1

in graves disease intially pt is hyperthyroid b/c of T4.
is it hypothyroid in the end if TSH goes down?
thanx.




  #2

Graves is autoimmune dss...TSH is low from the offset of dss...due to stimulatory effect of the a/b to TSH receptor on gland. So TSH will be low due to high T4. However, as the gland is useed up, T4 falls...pt becomes hypothyroid, and TSH goes up.


  #3

I think in Graves disease a person never becomes hypothyroid.

He shows hyperthyroidism initially and then hypothyroid features in Hashimotos thyroiditis

Correct me if I am wrong.

Amit Joshi


  #4

well i havent ever read anything like hypo as a consequence of graves dis. santaclara, have u read it somewhere?
mdwannabe, would u plz give the reference?


  #5

i don't remember exactly, but could be big Robbin's.


  #6

well i also study again this Q and i didn't find any where that in GRAVES disease initially pt is hyperthyroid and then hypo.
i think that is HASHIMOTO'S DISEASE.
in GRAVES as we know that this is an autoimmune disease and AB act directlt on thyroid tissue so b/c of this T4 increses in circulation and circulatory T4suppress the TSH.so this means hyperthyroid is due to T4 not b/cof TSH.and later on circulatory T4 suppress the TRH also.

well may be i m wrong.if so correct me and i will post any thing if i find it.
bye.


  #7

You're totally right Santaclara. TSI (TS immunglobulin) acts like TSH, stimulates folliculer cells of thyroid :arrow: T4 increase :arrow: TSH dec.





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