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 Goljan RR3: 1,25OHVitD in PHPT??  



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Hey guys,

One Q regarding Goljan RR3:

P. 496
3.d Increased serum 1,25-(OH)2D
* PTH increases synthesis of 1alfa-hydroxylase in proximal renal tubule

However, errata at www.healthsciences.okstate....dical/pathology/goljan.cfm
makes the following correction:

P. 496
3.d Decreased serum 1,25-(OH)2D
*Hypercalcemia decreases synthesis of 1alfa-hydroxylase in proximal renal tubule

Is this true? And what is the mechanism?

Have tried to google it, but only "evidence" I have come across is circumstantial, i.e. "calcitriol is decreased because it would exacerbate the problem"...







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