asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
Differentiate chediak higashi and bernard soulier ?
|
| dimps
Forum Guru
Topics: 63
Posts: 446
|
chediak higashi---autosomal recessive disorder
Mutations in the CHS1 gene. The primary defect is in intracellular granules, that results in chronic infection, decreased pigmentation in skin and eyes, neurological disease, and early death.
bernard soulier----In it there is the absent or decreased expression of the glycoprotein Ib/IX/V complex on the surface of the platelets. it is the receptor for von Willebrand factor (vWF), and the result of decreased expression is deficient binding of vWF to the platelet membrane at sites of vascular injury, resulting in defective platelet adhesion
___________________
hi how r u
|
| dmnz
Forum Junior
Topics: 7
Posts: 72
|
Chediak higashi- remember 5 'N's
Neutrohil chemotaxis defective
No pigmentation in eye and skin(oculocutaneous albinism)
Neuropathy
Neutropenia
Nystagmus
Neutrophils has large cytoplasmic granules
Notorious Bugs- staph & strepto-recurrent infections
Bernard soulier- defective platlet adhesion- Bad
dmnz :wink:
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
you r perfect dmnz 
|
|
| |
| | | | |
