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 chemokine receptor doubt  




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Author7 Posts
  #1

can any one tell me in pertussis they said inhibiting chemokine receptor causes lymphocytosis. can anyone plz explain me why is lymphocytosis
thank u




  #2

why??


  #3

cuz when chemokines will be inhibited ,, instead of lymphocytes being attracted to the site of infection,, they wont so they stay in the circulation leading to lymphocytosis,,,not sure but i remember reading this


On Sep 14, 2010 - 4:38 PM, step2010 responded:
after so many monthhs i got reply......thank u so much


  #4

Agree with ricardoricardo,Pertusis toxin causes inhibition of Gi-protein coupled chemokine receptor signaling which in turn causes inhibition of lymphocyte emigration from the blood into the target tissue.


  #5

Thanks for this response! ive been so confused!


  #6

I think is a bit more complex than that.


  #7

They stay in circulation because they are not able to go to the lymph nodes where they can have encounter with the APCs that may presenting the Ag to the T cell. That is why there is a relative lymphocytosis in a bacterial infection, which is not the general rule.





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