namf
Forum Elite
Topics: 80
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Hi gang!
I read that MHCI is expressed on all nucleated cells, and platelets.
Is MHCI then not on RBCs?
Thanks for answering! 
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| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
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RBC/... are they nucleated :-) ??? think about it :-)
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| namf
Forum Elite
Topics: 80
Posts: 312
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Hi mdwannabe,
Thanks for replying. I realize that RBCs are not nucleated; perhaps I could have better phrased my question as, "Despite lacking a nucleus, do RBCs have MHC-I?" If they don't I wonder how they present internal infections to the immune cells designed to destroy them should they become infected. Or does the spleen do that--and how, since I know the spleen checks for "plasticity" of RBCs by seeing if they can get through its cords. So does infection render the RBCs somehow less plastic..how??
Thanks a lot for your patience and help!
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| dariush
Forum Elite
Topics: 20
Posts: 356
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they DO NOT and i think that is why diseases like Malaria can get away with being destroyed. but never forget MHC does not tell the whole story. there are as you know Other surface proteins that although are not AG-presenting, they can ACT as AG when given to a wrong Donor (you get my point right? :wink: )
um not clear on Platelets though, are you really sure they have that?? that sounds odd; they are not even cells !! maybe you mean Megakaryocytes ?
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